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US 12,611,484 B2Granted
Silk-hyaluronic acid based tissue filers and methods of using the same
AssigneeEvolved By Nature, Inc.
InventorsGregory H. Altman, Peng Xu, Erlei Jin
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Abstract
Hyaluronic acid and silk protein fragments based tissue fillers and methods of using the same are provided herein.
Claims19
A biocompatible tissue filler, comprising hyaluronic acid (HA), and silk fibroin protein fragments (SPF) having an average weight average molecular weight selected from about 1 kDa to about 250 kDa and a polydispersity of between 1 and about 5.0,
- wherein a portion of the HA or SPF is modified or crosslinked by one or more linker moieties comprising one or more of an alkane or alkyl chain, an ether group, and a secondary alcohol, and
- wherein the tissue filler has a storage modulus (G′) of from about 25 Pa to about 1500 Pa.
Dependencies are inferred from the claim text.