Loading patent…
AssigneesCZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
InventorsChristina Smolke, Shireen S. Rudina
Estimating the term…
A novel ubiquitous chromatin opening element (UCOE) named SRF-UCOE and methods for its use are provided. Compositions including recombinant and synthetic SRF-UCOE nucleic acid molecules, DNA constructs and vectors comprising the SRF-UCOE nucleic acid molecules, host cells comprising the DNA constructs or vectors, and cell culture systems comprising such host cells. SRF-UCOE polynucleotide sequences can be used in DNA constructs or expression cassettes for transformation and expression in cells or organisms of interest. The compositions and methods provided are useful for increasing and/or maintaining expression of a gene of interest. Transgenic cells, tissues, and animals comprising a SRF-UCOE nucleotide sequence are also provided. Methods are provided for increasing and/or maintaining expression of a gene of interest and for treating a subject via gene therapy.
A recombinant nucleic acid molecule for controlling expression of a gene of interest (GOI) in a target cell, the nucleic acid comprising
A recombinant nucleic acid molecule for controlling expression of a gene of interest (GOI) in a target cell, the nucleic acid comprising:
A recombinant nucleic acid molecule for controlling expression of a gene of interest (GOI) in a target cell, the nucleic acid comprising:
Dependencies are inferred from the claim text.