Methods and immunogenic compositions relating to HER2 with selective sequence modifications
AssigneeWayne State University
InventorsWei-Zen Wei, Richard F. Jones, Joyce Reyes, Heather Gibson
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Abstract
Only limited success has been previously achieved from cancer vaccines targeting unmodified tumor-associated self-antigens and new compositions and methods are needed. Immunogenic compositions and methods of use thereof are provided according to the present disclosure which include a protein effective to stimulate immune activity against a tumor-associated self-antigen, or a variant thereof which is a tumor-associated self-antigen.
Claims7
A method of stimulating immune activity against a tumor-associated self-antigen, HER2, in a subject, comprising:
- administering a therapeutically effective amount of an immunogenic composition comprising:
- a protein, the protein consisting of:
- amino acid sequence SEO ID NO:2 to the subject.
A method of stimulating immune activity against a tumor-associated self-antigen, HER2, in a subject, comprising:
- administering a nucleic acid encoding a protein consisting of:
- amino acid sequence SEO ID NO:2, the nucleic acid encoding the protein operably linked to a heterologous regulatory nucleic acid sequence.
Dependencies are inferred from the claim text.