Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
AssigneeCity of Hope
InventorsMarcin Tomasz Kortylewski, Piotr Marek Swiderski, Dayson Friaca Moreira
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating an immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.
Claims23
An isolated compound comprising a phosphorothioated oligodeoxynucleotide conjugated to an antisense oligonucleotide of Signal Transducer and Activator of Transcription 3 (STAT3).
Dependencies are inferred from the claim text.