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US 12,611,447 B2Granted
Methods for treating bone mineralization disorders
AssigneeAlexion Pharmaceuticals, Inc.
InventorsAnna Petryk, Loredana Cuccia
Life of this patent
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Abstract
Featured are compositions and methods for treating bone mineralization disorders, such as hypophosphatasia (HPP). In some embodiments, the methods described herein are useful for treating adult subjects with HPP and/or treating or preventing bone fractures.
Claims19
A method of treating a mild phenotype of hypophosphatasia (HPP) in a human subject, wherein the subject exhibits a level in mean daily activity of at least one physical metric that identifies the subject as in need of treatment for the HPP, the method comprising:
- (a) administering at least one dose of a soluble alkaline phosphatase (sALP) having at least 90% sequence identity to SEQ ID NO:
- 1 to the subject in a first treatment phase of a treatment regimen;
- (b) intermittently or continuously monitoring the subject during the first treatment phase for changes in the at least one physical metric, wherein the physical metric is monitored using a wearable device;
- and
- (c) detecting an improvement in the at least one physical metric above a predetermined threshold of the metric and entering a first non-treatment phase of the treatment regimen during which the subject is not administered the sALP.
2 more elements
Dependencies are inferred from the claim text.