Approach to sustained production and delivery of nitric oxide and S-nitrosothiols

A method of treating a disease or condition in a subject, comprising administering to the subject a composition comprising a hygroscopic gelling agent and a nitrite source, wherein the nitrite source is entrapped within the gelling agent, wherein after being exposed to a sufficient amount of water, the composition releases a therapeutically effective amount of nitric oxide (NO), wherein the gelling agent is honey, wherein the disease or condition is selected from the group consisting of skin infections wounds, burns, leg ulcers, peripheral vascular disease, sinusitis, and outer ear infection.