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US 12,611,408 B2Granted
Methods for treating nail brittleness, fragility, or pitting
AssigneeChemistry RX
InventorLars Brichta
Life of this patent
Estimating the term…
Abstract
Compositions and methods for treating hair loss and/or nail brittleness, fragility, and pitting, particularly in pediatric patients, using topically administered JAK/STAT inhibitors and one or more penetration enhancer are described herein.
Claims7
A method for treating nail brittleness, fragility, or pitting comprising administering a topical composition to a subject in need thereof, wherein the composition comprises a JAK/STAT inhibitor, a base, a penetration enhancer, and an emulsifying agent, and wherein
- the JAK/STAT inhibitor is about 2% (w/w) of the total composition;
- the penetration enhancer is dimethyl sulphoxide (DMSO) and about 20% (w/w) of the total composition;
- the base is about 65% (w/w) to about 75% (w/w) of the total composition and is selected from the group consisting of white petrolatum, white petrolatum USP, mineral jelly, petroleum jelly, yellow petrolatum, yellow soft paraffin, white soft paraffin, fats, waxes, sterols, fat-soluble vitamins, monoglycerides, diglycerides, triglycerides, liposomal base, and combinations thereof;
- and
- the emulsifying agent is about 8% (w/w) of the total composition.
2 more elements
Dependencies are inferred from the claim text.