Compounds and their use for the treatment of ALPHA1-antitrypsin deficiency
AssigneeCentessa Pharmaceuticals (UK) Limited
InventorsNigel Ramsden, David John Fox, James Andrew Huntington, James Michael Tomlinson
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Abstract
The invention relates to specified carboxylic acid compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of α1-antitrypsin (A1AT) and may be used in the treatment of a disease or disorder such as α1-antitrypsin deficiency (A1AD or AATD).
Claims17
A method of inducing Z A1AT secretion in a subject in need thereof, comprising administering to the subject a compound represented by the structure:
- or a pharmaceutically acceptable salt of any one thereof.
A method of treating α1-antitrypsin deficiency (AATD), in a subject in need thereof, comprising administering to the subject a compound represented by the structure:
- or a pharmaceutically acceptable salt of any one thereof.
Dependencies are inferred from the claim text.