Use of ginkgolide a in the treatment of autism
AssigneesCenter for Excellence In Molecular Cell Science, Chinese Academy of Sciences, Guangzhou University
InventorsNaihe Jing, Ke Zhang, Ke Tang
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Abstract
Use of ginkgolide A in the treatment of autism. Specifically, the present invention relates to use of ginkgolide A, a stereoisomer thereof, a crystal form thereof, a pharmaceutically acceptable salt thereof, a derivative thereof, an extract comprising ginkgolide A, or a combination thereof in the preparation of a pharmaceutical composition for the treatment of autism. The experiments have demonstrated that ginkgolide A can significantly alleviate the behavioral defects of autism, and ginkgolide A has the advantages of small dosage and high safety when treating autism, and is very suitable as a common medicine for the treatment of autism.
Claims8
A method of treating autism spectrum disorder comprising the step of:
- administering to a subject having autism spectrum disorder a pharmaceutical composition consisting of (i) a therapeutically effective amount of ginkgolide A, a stereoisomer thereof, a crystal form thereof, a pharmaceutically acceptable salt thereof, a derivative thereof, or a combination thereof;
- and (ii) a pharmaceutically acceptable carrier,
- wherein the derivative of ginkgolide A is selected from the group consisting of 10-(2′-dimethylaminoethoxy)-ginkgolide A, 10-(2′-diethylaminoethoxy)-ginkgolide A, 10-((4′-methoxy-3′,5′-dimethyl-2′-pyridyl)-methoxy)-ginkgolide A, and 10-( (2′-yridyl)-ethoxy)-ginkgolide A, and
- wherein ginkgolide A, the stereoisomer thereof, the crystal form thereof, the pharmaceutically acceptable salt thereof, the derivative thereof, or the combination thereof is present at a weight percentage greater than 50% of the pharmaceutical composition.
Dependencies are inferred from the claim text.