Back to results
US 12,611,390 B2Granted
Methods and chemical compositions for treating skin conditions by providing long lasting skin PH control for improving skin barrier function
AssigneeSoteri Skin, Inc.
InventorRafal M. Pielak
Life of this patent
Estimating the term…
Abstract
Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.
Claims8
A method for treating atopic dermatitis, comprising:
- applying an effective amount of a composition with a buffer capacity concentration of composition acids and composition conjugate bases to a target skin area for a period of time to maintain the pH of the target skin area between 4.2 and 5.0;
- wherein the composition comprises:
- citric acid and sodium citrate comprising 1.5-15% weight of the composition, gluconic acid comprising 0.1-1.0% weight of the composition, glutamic acid comprising 0.1-1.0% weight of the composition, aspartic acid comprising 0.1-1.0% weight of the composition, histidine comprising 0.1-2.0% weight of the composition, with a pKa of 3.13, 4.76, or 6.0;
- shea butter comprising 8.7% weight of the composition,
- the shea butter comprising:
- oleic acid, stearic acid, palmitic acid, and linoleic acid with a pKa of 4.5;
- and
- free fatty acid content of 1% weight of the composition;
- sunflower oil comprising 6.5% weight of the composition,
- the sunflower oil comprising linoleic acid with a pKa of 4.5, and free fatty acid content of 1 percent;
- and
- an amino acid, peptide mix, or combination thereof, comprising 0.1-5% weight of the composition, with a range of pKa between 3.5 and 5.5.
9 more elements
A method for treating eczema, comprising:
- applying an effective amount of a composition with a buffer capacity concentration of composition acids and composition conjugate bases to a target skin area for a period of time to maintain the pH of the target skin area between 4.2 and 5.0;
- wherein the composition comprises:
- citric acid and sodium citrate comprising 1.5-15% weight of the composition, gluconic acid comprising 0.1-1.0% weight of the composition, glutamic acid comprising 0.1-1.0% weight of the composition, aspartic acid comprising 0.1-1.0% weight of the composition, histidine comprising 0.1-2.0% weight of the composition, with a pKa of 3.13, 4.76, or 6.0;
- shea butter comprising 8.7% weight of the composition,
- the shea butter comprising:
- oleic acid, stearic acid, palmitic acid, and linoleic acid with a pKa of 4.5;
- and
- free fatty acid content of 1% weight of the composition;
- sunflower oil comprising 6.5% weight of the composition,
- the sunflower oil comprising linoleic acid with a pKa of 4.5, and free fatty acid content of 1 percent;
- and
- an amino acid, peptide mix, or combination thereof, comprising 0.1-5% weight of the composition, with a range of pKa between 3.5 and 5.5.
9 more elements
Dependencies are inferred from the claim text.