US 12,611,385 B2 · Use of two-dimensional nanomaterial in inhibition of coronavirus

Abstract

Provided is the use of two-dimensional nanomaterials in the inhibition of a coronavirus, and specifically disclosed is the use of the two-dimensional nanomaterials in the preparation of a medicament for treating or preventing diseases caused by a coronavirus or of a material for adhering to or inhibiting the coronavirus. The two-dimensional nanomaterial is selected from the group consisting of copper indium thiophosphate (CIPS) nanosheet, graphene oxide nanosheet, molybdenum disulfide nanosheet, black phosphorus nanosheet and mixtures thereof. The coronavirus is selected from one of HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, SARS-CoV2 or MERS-CoV. The diseases caused by the coronavirus are diseases caused by coronavirus infection. The material has the advantages of being simple to prepare, having a high biological safety and an excellent effect.

Claims9

Dependent claims

A method of treating coronavirus-induced disease, comprising:

administering to a subject in need thereof a composition comprising a two-dimensional nanomaterial,
wherein the two-dimensional nanomaterial is copper indium thiophosphate nanosheet;
wherein the two-dimensional nanomaterial inhibits binding of a spike protein of a coronavirus to a receptor ACE2 of a host cell thereof through competitively binding to a receptor binding domain (RBD) of the spike protein;
and
wherein the coronavirus is selected from one of HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, SARS-CoV2, and MERS-CoV;
and the coronavirus-induced disease is a disease caused by coronavirus infection.

3 more elements

A material for adsorbing or inhibiting a coronavirus, comprising a two-dimensional nanomaterial and a matrix,

wherein the two-dimensional nanomaterial is copper indium thiophosphate nanosheet;
wherein the two-dimensional nanomaterial inhibits binding of a spike protein of a coronavirus to a receptor ACE2 of a host cell thereof through competitively binding to a receptor binding domain (RBD) of the spike protein;
and
wherein the coronavirus is selected from one of HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-COV, SARS-COV2, and MERS-COV.

1 more element

Dependencies are inferred from the claim text.

Use of two-dimensional nanomaterial in inhibition of coronavirus

Life of this patent

Use of two-dimensional nanomaterial in inhibition of coronavirus

Life of this patent

Abstract

Claims9