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US 12,611,375 B2Granted
Injectable slurries and methods of manufacturing the same
AssigneeThe General Hospital Corporation
InventorsLilit Garibyan, William A. Farinelli, Richard Rox Anderson, Emilia Javorsky
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Abstract
A method for treating vascular diseases is provided. The method includes fabricating a sterile ice slurry including water and ice particles, cooling the sterile ice slurry to a predetermined temperature, and injecting the sterile ice slurry into a desired tissue region. The desired tissue region includes perivascular adipose tissue.
Claims7
A method for treating lipomyelomeningocele (LMM) associated with abnormal fat accumulation in a human subject by tissue cooling, the method comprising:
- cooling a non-frozen sterile slurry composition to a predetermined temperature, wherein the predetermined temperature is sufficient to form a plurality of ice crystals in the sterile slurry composition;
- administering the sterile slurry composition having the plurality of ice crystals to a target tissue region, wherein the target tissue region comprises adipose tissue proximate to the spinal cord;
- and
- cooling the target tissue region for a duration sufficient to reduce the adipose tissue within the target tissue region.
1 more element
Dependencies are inferred from the claim text.