Skin mimicry compositions and implants
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsOded Shoseyov, Chen Nowogrodski, Yaniv Damatov
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Abstract
Provided are systems, compositions, methods and devices for manufacturing artificial skin substitutes and related products mimicking the morphology and appearance of human skin. Applications of the invention pertain to the fields of regenerative medicine and pharma with products that can support tissue replacement and tissue engineering. The most immediate applications pertain to the field of cosmetics with the development of pigmented compositions that can be incorporated in various skin care and cosmetic foundation products.
Claims20
A compound comprising a keratin backbone bonded to a plurality of melanin units, each melanin unit having a structure derived from oxidation of L-Dopa onto a hydrolyzed cysteine moiety of the keratin backbone (designated herein KERMEL).
A skin mimicking system comprising at least one of:
- (1) a composition comprising or consisting of a compound comprising a keratin backbone bonded to a plurality of melanin units, each melanin unit having a structure derived from oxidation of L-Dopa onto a hydrolyzed cysteine moiety of the keratin backbone (KERMEL);
- and
- (2) a composite structure comprising a two-sided SC like keratin-melanin layer with an upper face layer comprising a color, a tone and/or a trait that substantially similar to the color, tone and/or trait of a human skin or hair, and a lower face comprising a 3D structure that is substantially similar to the papillary dermo-epidermal junction structure of human skin (potable epidermal model, PEM).
Dependencies are inferred from the claim text.