Biosensor performance indicator systems for orthodontic appliances

An orthodontic appliance system comprising:

• a shell having a plurality of tooth receiving cavities configured to receive a plurality of teeth and to exert one or more orthodontic repositioning forces on the plurality of teeth;
• and
• at least one biosensor system comprising:
• a bioreceptor configured to cause an interaction with a biomarker in fluid in an oral cavity, the biomarker associated with a velocity of tooth root movement;
• and
• a biotransducer coupled to the bioreceptor, the biotransducer configured to transduce the interaction into an interaction signal representative of the interaction;
• and
• a processor configured to receive sensor data corresponding to the interaction signal and, based on the sensor data, provide one or more recommendations to change an orthodontic appliance when the interaction signal is below a threshold, wherein the one or more recommendations to change the orthodontic appliance includes a recommendation to use a subsequent orthodontic appliance of a next stage of an orthodontic treatment plan.