Absorptive tip brush biopsy device, kit and method

A flexible coaxial tissue sampling device, comprising:

• a sheath;
• a displaceable wire within the sheath, the displaceable wire having a first end extending from a proximal end of the sheath and second end configured, in a first state, to extend from a distal end of the sheath, and in a second state, to retract into the distal end of the sheath;
• an atraumatic bulb covered with a porous absorptive material comprising a polymeric foam, formed on the second end of the displaceable wire, the atraumatic bulb covered with the porous absorptive material being sized and configured to be withdrawn into the sheath by tension on the first end of the displaceable wire;
• the second end of the displaceable wire comprising a piston, a cellular sampling structure configured to disrupt a tissue surface to dislodge cells, and the porous absorptive material being configured to draw in and retain a fluid sample comprising cellular material, wherein the cellular sampling structure and the porous absorptive material are external to the sheath in the first state and the cellular sampling structure is internal to the sheath in the second state and the piston is proximal to the cellular sampling structure with respect to the porous absorptive material;
• the flexible coaxial structure being configured such that a tension on the first end of the displaceable wire at the proximal end of the sheath results in a retraction of the displaceable wire from the first state to the second state, to cause a displacement into the sheath of the displaceable wire and a corresponding proximal displacement of the piston, the cellular sampling structure, and the porous absorptive material, with suction of media external to the sheath into the distal end of the sheath, the porous absorptive material being configured to retain the fluid sample comprising cellular material obtained in the first state after transition to the second state,
• wherein the coaxial structure is configured to be inserted to a determined depth through an internal cervical os of a uterus of a human, to retrieve an endometrial biopsy sample, and to be withdrawn from the cervix.