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US 12,611,016 B2Granted
Cationic contact lens
AssigneeCooperVision International Limited
InventorsYuan Ji, Yuwen Liu, Victoria Rogers, Hyo Jeang Lee, Erwin C. Si, Nancy J. Keir
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AssigneeCooperVision International Limited
InventorsYuan Ji, Yuwen Liu, Victoria Rogers, Hyo Jeang Lee, Erwin C. Si, Nancy J. Keir
Estimating the term…
A cationic contact lens is described as well as methods of manufacturing the same. The cationic contact lens includes a polymeric lens body that is the reaction product of a polymerizable composition that includes at least one siloxane, at least one nonionic hydrophilic monomer and at least one acyclic tertiary amine monomer. The cationic contact lens can be an unworn sterile silicone hydrogel contact lens. The contact lens is capable of substantially linear release of a releasable anionic agent and the at least one acyclic tertiary amine monomer facilitates uptake and/or sustained release of the releasable anionic agent by the polymeric lens body. The contact lens can be present in a sealed contact lens package. The sealed contact lens package can include at least a) a base member having a cavity; b) a contact lens packaging solution in the cavity; c) a unworn sterile contact lens immersed in the contact lens packaging solution in the cavity with the releasable anionic agent present; and d) a cover that forms a liquid-tight seal with the base member.
An unworn sterile silicone hydrogel contact lens immersed in a packaging solution and sealed in a package, said contact lens comprising:
A silicone hydrogel contact lens comprising a polymeric lens body that is the reaction product of a polymerizable composition comprising:
An unworn sterile silicone hydrogel contact lens comprising a polymeric lens body that is the reaction product of a polymerizable composition comprising (a) from 15 wt. % to 65 wt. % of at least one siloxane monomer, (b) from 25 wt. % to 75 wt. % of at least one nonionic hydrophilic monomer, (c) from 0.1 wt. % to 15 wt. % of at least one acyclic tertiary amine monomer, and (d) from about 1 wt. % to about 20 wt. % of a hydrophobic monomer selected from methyl methacrylate (MMA), isobornyl methacrylate (IBM), or 2-hydroxybutyl methacrylate (HOB) or any combination thereof, and said unworn sterile silicone hydrogel contact lens is capable of substantially linear release of a releasable anionic agent at a release rate of at least 6 μg/hr for at least 8 hours when tested in an in vitro release assay, wherein the releasable anionic agent is at least one acid having a single carboxylic acid group and has a molecular weight of less than about 900 Daltons;
Dependencies are inferred from the claim text.