Method of generating a metric to quantitatively represent an effect of a treatment
AssigneeHoffmann-La Roche Inc.
InventorsOliver Grimm, Marta Canamero
Life of this patent
Estimating the term…
Abstract
Methods of generating a metric to quantitatively represent an effect of a treatment are disclosed. In one arrangement, first and second sample data units are received, each representing a segmented image of a biological sample taken from a subject. The segmentation divides the image into plural segmentation sets of regions. Each of the first and second sample data units is analysed to determine information about a spatial distribution of biomarkers relative to the segmentation sets. A metric is generated using a combination of the determined information about the spatial distribution of biomarkers relative to the segmentation sets for the first and second sample data units.
Claims17
A computer-implemented method of generating a metric to quantitatively represent an effect of a treatment, the method comprising:
- receiving a first sample data unit derived from a subject before a treatment has been applied and receiving a second sample data unit derived from the subject after the treatment has been applied, or
- receiving a first sample data unit derived from a subject after a first treatment has been applied to the subject and receiving a second sample data unit derived from the subject after a second treatment has been applied to the subject, the second treatment being different from the first treatment;
- and
- wherein each of the sample data units represents a segmented image of a biological sample taken from the subject, the segmentation dividing the image into plural segmentation sets of regions, each segmentation set representing regions in the image that correspond to a different respective tissue type;
- and
- wherein the method further comprises:
- analysing each of the first sample data unit and the second sample data unit to determine information about a spatial distribution of biomarkers relative to the segmentation sets;
- and
- generating a metric using a combination of the determined information about the spatial distribution of biomarkers relative to the segmentation sets for the first sample data unit and the second sample data unit,
- wherein the information about the spatial distribution of biomarkers relative to the segmentation sets comprises:
- first information, comprising information about the spatial distribution of biomarkers in a first one of the segmentation sets;
- and
- second information, comprising information about the spatial distribution of biomarkers in a second one of the segmentation sets,
- where the metric is generated using the first and second information for the first sample data unit and the first and second information for the second sample data unit, and
- wherein the generation of the metric comprises obtaining a vector having end points defined by the first and second information for the first sample data unit and the first and second information for the second sample data unit.
Dependencies are inferred from the claim text.