Dopaminergic imaging to predict treatment response in mental illness
AssigneeKing's College London
InventorsOliver Howes, Mattia Veronese
Life of this patent
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Abstract
A neuroimaging-based approach to predict treatment response in mental disorders by acquiring and analysing brain PET dopamine measures from patients. The method uses a short, simplified protocol for [18F]FDOPA brain PET imaging adapted for clinical practice. Individual [18F]FDOPA brain PET data are then quantified with a fully-automated analysis pipeline to extract information on the dopamine function of the subject. This information coupled with clinical information is run through a prediction algorithm to identify those patients whose illness will not respond to conventional antipsychotics.
Claims19
A method of predicting treatment response of a patient with a mental disorder comprising:
- receiving a map of a patient's brain displaying uptake of a DOPA labelled radiotracer;
- and
- inputting the map and patient data into a prediction algorithm, which outputs a prediction of whether the patient will not respond to standard treatment, wherein the algorithm has been trained on:
- (a) an existing DOPA labelled radiotracer PET dataset from patients with a mental disorder which have responded to standard treatment;
- (b) images of patients which did not response to standard treatment;
- and (c) control images.
A system for predicting treatment response of a patient with a mental disorder, the system comprising:
- a processor;
- and
- a memory including computer program code
- the memory and the computer program code configured to, with the processor, cause the apparatus to perform of predicting treatment response of a patient with a mental disorder comprising:
- receiving a map of a patient's brain displaying uptake of a DOPA labelled radiotracer;
- and
- inputting the map and patient data into a prediction algorithm, which outputs a prediction of whether the patient will not respond to standard treatment, wherein the algorithm has been trained on:
- (a) an existing DOPA labelled radiotracer PET dataset from patients with a mental disorder which have responded to standard treatment;
- (b) images of patients which did not response to standard treatment;
- and (c) control images.
Dependencies are inferred from the claim text.