Back to results
US 12,607,634 B2Granted
Methods and compositions for assessing immune response in murine tumor models
AssigneeCrown Bioscience (Suzhou) Inc.
InventorsJia Xue, Xiaobo Chen, Sheng Guo, Henry Li
Life of this patent
Estimating the term…
Abstract
The disclosure provides methods and compositions, e.g., kits and microarray, for assessing the immune response in a murine tumor model based on the expression of a gene panel that characterizes tumor immune interactions.
Claims22
A method for assessing immune response in a murine model, the method comprising:
- obtaining a sample from the murine model;
- detecting the expression level of a panel of genes in the sample, wherein the panel comprises 1080 genes as shown in Table 1;
- comparing the expression level of the panel to a reference expression level;
- and
- assessing the immune response in the murine model.
2 more elements
A method for evaluating a treatment in a murine model, comprise
- administering a treatment to a murine model;
- obtaining a sample from the murine model;
- detecting the expression level of a panel of genes in the sample, wherein the panel comprises 1080 genes as shown in Table 1;
- comparing the expression level of the panel to a reference expression level;
- and
- evaluating the immune response in the murine model.
3 more elements
A kit for assessing immune response in a murine model comprising primers for detecting the expression of a panel of genes in a sample from the murine model, wherein the panel comprises 1080 genes as shown in Table 1.
Dependencies are inferred from the claim text.