Biological and/or biochemical and/or chemical sensor

A biological and/or biochemical and/or chemical sensor, comprising:

• a prism;
• a first metal layer comprising a contact face covering a first face of the prism;
• a light source configured to emit light radiation at an angle of incidence θi on the contact face;
• a detector configured to collect the light radiation emitted by the light source and reflected by the contact face;
• a second layer comprising dielectric material covering the first metal layer;
• and
• a transistor resting on the second layer,
• wherein the transistor comprises a channel region provided in a first sheet comprising a two-dimensional material,
• wherein the first sheet has a rear face resting on the second layer, and a front face, opposite the rear face,
• wherein the front face of the first sheet comprises a functionalization comprising specific probes suitable for absorbing one or more specific targets of a target family, and
• wherein the functionalization is configured to place adsorbed specific targets at a distance lower than a detection distance Dd, below which combined detection by electrical measurement with the transistor and by surface plasmon resonance measurement is possible.