Method for diagnosing and monitoring inflammatory disease progression
AssigneesThe Regents of the University of California, McMaster University
InventorsWarren Foster, Jocelyn Wessels, Sanjay Agarwal, Leyla Soleymani
Life of this patent
Estimating the term…
Abstract
Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF, glycodelin and optionally ZAG, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.
Claims15
A method of diagnosing endometriosis in a human, the method comprising:
- detecting an expression level of circulating brain-derived neurotrophic factor (BDNF) in a biological fluid sample taken from the human;
- comparing the circulating BDNF expression level to a BDNF control level to determine if the circulating BDNF level is elevated as compared to the control level, wherein the control level is an expression level of BDNF in a human without endometriosis;
- diagnosing the human with endometriosis when the circulating BDNF expression level is elevated by at least 10% as compared to the BDNF control level;
- and
- further diagnosing a stage of the endometriosis if present, wherein elevation of the circulating BDNF expression level by 30% to 50% as compared to the BDNF control level is indicative of stage 1 or stage 2 endometriosis.
A method of diagnosing endometriosis in a human with pelvic pain, the method comprising:
- detecting an expression level of circulating brain-derived neurotrophic factor (BDNF) in a biological fluid sample taken from the human with pelvic pain;
- comparing the circulating BDNF expression level to a BDNF control level to determine if the circulating BDNF level is elevated as compared to the control level, wherein the control level is an expression level of BDNF in a human without endometriosis;
- and
- diagnosing the human with endometriosis when the circulating BDNF expression level is elevated as compared to the BDNF control level.
A method of diagnosing endometriosis in a human, the method comprising:
- detecting the expression level of circulating brain-derived neurotrophic factor (BDNF) and cancer antigen 125 (CA-125) in a biological fluid sample taken from the human;
- comparing the circulating expression levels of BDNF and CA-125 to control levels of BDNF and CA-125 to determine if the circulating BDNF and CA-125 levels are elevated as compared to the control levels, wherein the control levels are expression levels of each of BDNF and CA-125 in a human without endometriosis;
- and
- diagnosing the human with endometriosis when one or both of the circulating BDNF and CA-125 expression levels are elevated as compared to the BDNF and CA-125 control levels.
Dependencies are inferred from the claim text.