Recombinant virus, composition comprising the same, and uses thereof
AssigneeAcademia Sinica
InventorsChi-Huey Wong, Chung-Yi Wu
Life of this patent
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Abstract
Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.
Claims4
A method of preparing a recombinant Influenza A virus (IAV) comprising a mutant neuraminidase (NA), the method comprising introducing individual plasmids coding for 8 genomic segments of an influenza A virus into a cultured cell, wherein the genomic segment of the NA protein is mutated by introducing a stop codon by site-directed mutagenesis which result in the mutant NA consists of the amino acid sequence of SEQ ID NO:
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Dependencies are inferred from the claim text.