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US 12,606,937 B2Granted
Humanized antibodies with ultralong complementary determining regions
AssigneeTaurus Biosciences, LLC
InventorsOmar Bazirgan, Miguel De Los Rios
Life of this patent
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Abstract
The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
Claims10
An antibody comprising:
- (a) a modified heavy chain variable domain comprising, in order:
- (i) a FR1-CDR1-FR2-CDR2-FR3 region comprising the FR1, FR2 and FR3 of the human germline VH4-34 variable domain (SEQ ID NO:
- 33) with the exception of at least one amino acid substitution selected from Q5R, Q6E, and E50S, and up to 5 additional amino acids substitutions at positions other than positions 5, 6, and 50;
- (ii) an ultralong CDR3 that is at least 35 amino acids in length;
- and
- (iii) a framework region 4 (FR4);
- and
- (b) a light chain variable domain.
5 more elements
Dependencies are inferred from the claim text.