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US 12,606,873 B2Granted
Detecting neoplasm
AssigneesMayo Foundation for Medical Education and Research, Exact Sciences Corporation
InventorsDavid A. Ahlquist, John B. Kisiel, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
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Abstract
Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
Claims14
A method comprising:
- treating DNA from a biological sample obtained from a subject with a reagent that modifies DNA in a methylation-specific manner;
- amplifying the treated DNA using primers specific for at least one CpG site in OSR2, and at least one CpG site in SIM2 and/or FER1L4;
- and
- measuring a methylation level of the at least one CpG site in OSR2, and the at least one CpG site in SIM2 and/or FER1L4.
1 more element
Dependencies are inferred from the claim text.