Molecular signature
AssigneeUCL Business PLC
InventorsVitor Hugo De Sousa Teixeira, Samuel Janes, Christodoulos P. Pipinikas, Adam James Pennycuick
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Abstract
The present invention relates to a method of identifying a pre-invasive lung lesion in an individual that will progress to an invasive lung cancer involving determining the presence or absence of a molecular signature. The present invention also relates to a method of treating a pre-invasive lung lesion and/or treating and/or preventing an invasive lung cancer in an induvial comprising involving determining the presence or absence of a molecular signature. The present invention further relates to a molecular signature, and uses thereof, for identifying whether or not an individual has a pre-invasive lung lesion that will progress to an invasive lung cancer.
Claims14
A method comprising:
- (a) providing a sample of nucleic acid which has been taken from a lung squamous cell carcinoma (LUSC) tissue of a subject;
- (b) measuring a differentially methylated position (DMP) signature comprising positions cg07716946 and cg04786287 in the sample;
- (c) detecting a change in methylation status at positions cg07716946 and cg04786287 compared to control samples;
- and
- (d) administering an effective amount of lung cancer therapy to the subject with a change in methylation status at positions cg07716946 and cg04786287.
A method comprising:
- (a) providing a sample of nucleic acid which has been taken from a pre-invasive lung lesion tissue of a subject;
- (b) measuring a differentially methylated position (DMP) signature comprising positions cg07716946 and cg04786287 in the sample;
- (c) detecting a change in methylation status at positions cg07716946 and cg04786287 compared to control samples;
- and
- (d) administering an effective amount of lung cancer therapy to the subject with a change in methylation status at positions cg07716946 and cg04786287.
Dependencies are inferred from the claim text.