Compounds for treatment of osteoarthritis
AssigneeAltos Labs, Inc.
InventorsMaddalena Adorno, Benedetta Nicolis Di Robilant, Amit Umesh Joshi
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Abstract
The present disclosure relates to methods of treating osteoarthritis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a USP16 inhibitor.
Claims20
A method of treating osteoarthritis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a USP16 inhibitor.
A method of treating a disease or disorder in a subject in need thereof, the method comprising contacting a mesenchymal stem cell (MSC) with a USP16 inhibitor and administering the MSC to the subject.
A method of protecting chondrogenic potential or self-renewal in mesenchymal stem cells, the method comprising contacting the mesenchymal stem cells with an effective amount of a USP16 inhibitor.
A method of increasing cartilage production or proliferation of a chondrocyte or inhibiting senescence in a chondrocyte, the method comprising contacting the chondrocyte with an effective amount of a USP16 inhibitor.
Dependencies are inferred from the claim text.