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US 12,606,814 B2Granted
Oligonucleotide probes and uses thereof
AssigneeCaris Science, Inc.
InventorsValeriy Domenyuk, Tassilo Hornung, Mark Miglarese, David Spetzler
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Abstract
Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
Claims20
A method of enriching an oligonucleotide probe library comprising a plurality of oligonucleotides, the method comprising:
- (a) providing a planar support arrayed with a plurality of samples, wherein a portion of the plurality of samples differs from another portion of the plurality of samples according to a phenotype of interest;
- (b) contacting the plurality of samples arrayed on the planar support with the plurality of oligonucleotides;
- and
- (c) recovering members of the oligonucleotide probe library that bound to members of the portion of samples of one phenotype of interest, thereby enriching the oligonucleotide probe library.
1 more element
Dependencies are inferred from the claim text.