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US 12,606,808 B2Granted
Mirror nucleic acid replication system
AssigneeTsinghua University
InventorsTing Zhu, Lei Liu, Weiliang Xu, Zimou Wang, Wenjun Jiang, Jiaxing Wang, Linping Yu
Life of this patent
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Abstract
Provided is a method for replicating a mirror nucleic acid, comprising: reacting a mirror nucleic acid template, a mirror nucleic acid primer and mirror dNTPs/rNTPs in the presence of a mirror nucleic acid polymerase, so as to obtain the mirror nucleic acid.
Claims12
A composition comprising a nucleic acid polymerase in a D-form of Dpo4 protein of Sulfolobus solfataricus which comprises one or more amino acid mutations selected from the group consisting of NI23A, S207A and S313A relative to a wild-type Dpo4 protein as set forth in the sequence of SEQ ID NO:
- 45.
Dependencies are inferred from the claim text.