Tymovirus virus and virus-like particles as nanocarriers for imaging and therapeutic agents
AssigneeCase Western Reserve University
InventorsNicole F. Steinmetz, Hema Masarapu, He Hu
Life of this patent
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Abstract
A method of targeting cancer tissue in a subject includes administering to the subject a plurality of functionalized Tymovirus virus or virus-like particles loaded with or conjugated to an imaging agent, a therapeutic agent or a targeting agent.
Claims19
A nanoparticle, comprising a Tymovirus virus or Tymovirus virus-like particle (VLP) that has been loaded with or conjugated to a cancer-specific targeting agent, and one or more of an imaging agent, or an anticancer agent.
A nanoparticle, comprising a Tymovirus virus or Tymovirus virus-like particle (VLP) that has been loaded with or conjugated to multiple cancer-specific targeting agents and one or both of an anticancer agent or an imaging agent wherein the spacing and location of targeting agents on each Tymovirus virus or VLP is controlled to facilitate delivery and/or targeting of the Tymovirus virus or VLP.
Dependencies are inferred from the claim text.