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US 12,606,804 B2Granted
Influenza virus backbone
AssigneeFluGen, Inc.
InventorsMichael J. Moser, Yasuko Hatta, Pamuk Bilsel, Lindsay Hill-Batorski
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Abstract
The invention provides an influenza virus that demonstrates enhanced growth in Vero cells. The influenza virus includes PA, NP, and NS gene segments having selected nucleotides and encoding proteins having amino acid sequences with selected amino aids. The invention also provides a pharmaceutical formulation containing the influenza virus, as well as a method of eliciting an immune response in a mammal by administering the influenza virus to the mammal, and a method for generating the influenza virus.
Claims28
An influenza virus comprising PA, NP, and NS gene segments, wherein
- (a) the PA gene segment comprises a thymine at nucleotide position 2272;
- (b) the NP gene segment encodes a NP protein having an amino acid sequence comprising selected amino acids, wherein the selected amino acids comprise a serine at position 40, an asparagine or glycine at position 161, a threonine at position 204, and optionally a valine at position 93;
- and
- (c) the NS gene segment comprises a guanine at nucleotide position 39, and the NS gene segment encodes an NS1 protein having an amino acid sequence comprising selected amino acids, wherein the selected amino acids comprise a glutamine at position 176.
1 more element
Dependencies are inferred from the claim text.