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US 12,606,796 B2Granted
Delivery of oncolytic viruses using dendritic cells
AssigneeSator Therapeutics
InventorsPeter M. Chumakov, Darya A. Berzhitskaya, Anastasia V. Lipatova, Stepan P. Chumakov, Natalia D. Tararova, Stephen A. Charles, Anton A. Komar
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Abstract
A versatile carrier system for systemic delivery of oncolytic viruses comprises dendritic cells having at least one oncolytic virus loaded therein. It is believed that the dendritic cells will protect the oncolytic virus(es) against neutralizing antibodies, can transport the oncolytic virus(es) to targeted tumor locations, and then deliver virions to the tumor locations.
Claims7
A method of treating a cancer patient, comprising:
- administering to the patient a composition comprising dendritic cells loaded therein with a complex of (a) an oncolytic virus and (b) a neutralizing antibody for the oncolytic virus;
- wherein the at least one oncolytic virus is vaccinia.
A method for treating a cancer patient, comprising:
- administering to the patient a first therapeutic composition comprising dendritic cells loaded therein with a complex of (a) a first oncolytic virus and (b) a neutralizing antibody for the first oncolytic virus;
- measuring loads of the first oncolytic virus in blood samples collected at different time points;
- and
- when the load of the first oncolytic virus reaches a threshold value, administering to the patient a second therapeutic composition comprising dendritic cells loaded therein with a complex of (a) a second oncolytic virus and (b) a neutralizing antibody for the second oncolytic virus, wherein the first oncolytic virus and the second oncolytic virus are different from each other;
- and
- wherein either the first oncolytic virus or the second oncolytic virus is vaccinia.
3 more elements
Dependencies are inferred from the claim text.