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US 12,606,788 B2Granted
Perfusion filter membrane assembly
AssigneeGlobal Life Sciences Solutions USA LLC
InventorsDouglas Albagli, William A. Hennessy, Ralph Stankowski
Life of this patent
Estimating the term…
Abstract
Filter holders and membranes are provided that can be included within a bioreactor bag system. The filter holders and membranes include features that allow incorporation of advanced membrane materials having differing material characteristics than traditional membranes that more closely matched the characteristics of the filter holder.
Claims14
A perfusion filter assembly comprising:
- a plurality of standoffs, the plurality of standoffs positioned on a bottom surface;
- a filter holding device adapted to engage the plurality of standoffs;
- a filter membrane, the filter membrane comprising:
- a porous filter region, the porous filter region comprising a plurality of pores having a pore dimension within a range of 20 nm and less than 100 microns;
- and
- a membrane frame region surrounding the porous filter region, where the membrane frame region comprises a plurality of openings adapted to engage the plurality of standoffs;
- a seal abutting the filter membrane;
- and
- a support frame adapted to engage with the filter holding device and the plurality of standoffs and secure the filter membrane and the seal between the filter holding device and the support frame, the filter membrane being spaced from the bottom surface by way of the plurality of standoffs.
6 more elements
A flexible bag bioreactor comprising:
- an inner surface and an outer surface;
- a perfusion filter assembly, the perfusion filter assembly comprising:
- a plurality of standoffs;
- a filter holding device adapted to engage the plurality of standoffs;
- a filter membrane, the filter membrane comprising:
- a porous filter region, the porous filter region comprising a plurality of pores having a pore dimension within a range of 20 nm and less than 100 microns;
- and
- a membrane frame region surrounding the porous filter region,
- where the membrane frame region comprises a plurality of openings adapted to engage the plurality of standoffs;
- a seal abutting the filter membrane;
- and
- a support frame adapted to engage with the filter holding device and the plurality of standoffs and secure the filter membrane and the seal between the filter holding device and the support frame within the perfusion filter assembly, wherein the perfusion filter assembly is attached to the inner surface of the flexible bag via the plurality of standoffs such that the filter membrane held by the perfusion filter assembly is provided at least a distance from the inner surface of the flexible bag.
9 more elements
Dependencies are inferred from the claim text.