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US 12,606,773 B2Granted
Ionizable cationic lipids
AssigneeAkagera Medicines, Inc.
InventorsDaryl C. Drummond, Dmitri B. Kirpotin, Mark E. Hayes
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Abstract
The present disclosure provides compounds useful as ionizable cationic lipids. The ionizable cationic lipids are useful for preparing lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids were engineered with improved stability to oxidative degradation while in storage.
Claims18
A compound having a structure of Formula (IV)
- wherein n is 1, 2, 3 or 4;
- or pharmaceutically acceptable salt thereof, wherein Y is
- wherein each R22 is independently alkyl, alkenyl, alkynyl, or heteroalkyl, each of which is substituted with RB;
- each RB is a disulfide linkage;
- and denotes the attachment point.
2 more elements
Dependencies are inferred from the claim text.