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US 12,606,719 B2Granted
Methods and compositions comprising biodegradable cyanoacrylates
AssigneeFemasys Inc.
InventorKathy Lee-Sepsick
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Abstract
Disclosed herein are methods of making and using cyanoacrylate compositions comprising one or more cyanoacrylates, a high level of at least one stabilizing agent and at least one free-radical polymerization inhibitor. Methods disclosed comprise making such compositions and using such compositions, for example, for occluding conduits such as fallopian tubes.
Claims7
A biodegradable cyanoacrylate composition, consisting essentially of,
- a) a cyanoacrylate component consisting of methoxyisopropyl cyanoacrylate and methoxypropyl cyanoacrylate, wherein the cyanoacrylate component is 99 wt % or greater of the total weight of the biodegradable cyanoacrylate composition;
- b) a stabilizer component of sulfur dioxide in a range from 600 ppm to 1500 ppm;
- and
- c) a polymerization inhibitor component of butylated hydroxy anisole (BHA) in a range from 4000 to 7000 ppm,
- wherein the viscosity of the composition is from about 10 cP to about 30 cP;
- with a cure or setting time between 10 seconds and 30 seconds;
- and
- wherein the composition fails to pass a Neutral Red cytotoxicity test (as measured by ISO 10993-5:2009) and passes genotoxicity testing (as measured by ISO 10993-3:2003).
5 more elements
A biodegradable cyanoacrylate composition, comprising,
- a. a cyanoacrylate component consisting of methoxyisopropyl cyanoacrylate and methoxypropyl cyanoacrylate, wherein the cyanoacrylate component is 99 wt % or greater of the total weight of the biodegradable cyanoacrylate composition;
- b. a stabilizer component of sulfur dioxide in a range from 600 ppm to 1500 ppm;
- and
- c. a polymerization inhibitor component of butylated hydroxy anisole (BHA) in a range from 4000 to 7000 ppm.
1 more element
Dependencies are inferred from the claim text.