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US 12,606,641 B2Granted
Amphiphilic carbohydrate compounds
AssigneeNanomerics LTD
InventorRyan Mellor
Life of this patent
Estimating the term…
Abstract
The present invention relates to an acetylated amphiphilic carbohydrate compound of average molecular weight 1-50 kDa which is based on a glycol chitosan, wherein the levels of acetylation can be modified. The compound can be formulated with hydrophobic compounds such as drugs. The degree of acetylation of the carbohydrate compound is optimised to maximise solubilisation of the drugs. The compound is formulated with drugs and is useful in therapy.
Claims19
An amphiphilic carbohydrate compound of average molecular weight 1-50 kDa of formula (I):
- wherein:
- the level of unit A is from 2% to 27 mole %;
- the level of unit D is from 1% to 95.5 mole %;
- the level of unit H is from 1% to 95.5 mole %;
- the level of unit Q is from 1% to 90 mole %;
- the level of unit T is from 0% to 94.5 mole %;
- R1, R2, R3, R4 and R10 are independently hydrogen or any linear, branched or cyclo form of an alkyl, alkenyl, alkynyl, aryl, acyl group or polyoxyalkylene with C1-C3 alkylene units, optionally substituted with amine, amide or alcohol;
- R5 is a hydrophobic, substituted or unsubstituted, linear, branched or cyclo form of a C4-30 alkyl, C4-30 alkenyl, C4-30 alkynyl, C4-30 aryl, amine, C4-30 amide, C4-30 alcohol or C3-30 acyl group;
- R6, R7, and R8 are independently any linear, branched, or cyclo forms of any alkyl, alkenyl, alkynyl, aryl or acyl group;
- R9 is present or absent and, when present, is a substituted or unsubstituted alkyl group, a substituted or unsubstituted amine group or a substituted or unsubstituted amide group;
- R11 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group or a substituted or unsubstituted alkene group or hydrogen;
- and
- R12 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group or a substituted or unsubstituted alkene group;
- R13 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group or a substituted or unsubstituted alkene group or hydrogen;
- or a salt thereof;
- wherein the A, D, H and Q units form a linkage of any arrangement and * is used to represent the continuing polymer chain.
13 more elements
Dependencies are inferred from the claim text.