Glypican-2-binding moieties, chimeric antigen receptors and uses thereof
AssigneeNanjing Legend Biotech Co., Ltd.
InventorsWang Zhang, Jintao Guo, Fengyuan Tang, Shuai Yang, Yuanyuan Peng, An Tang, Xiaojie Tu, Yunlei Liu, Shu Wu
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Abstract
The present application provides GPC2-specific antibodies and antigen binding fragments thereof. A chimeric antigen receptor (CAR) that specifically binds glypican-2 (GPC2) comprising a GPC2-specific antibody, a transmembrane domain, and an intracellular signaling domain. T cells comprising the disclosed CAR constructs can be used for cancer immunotherapy.
Claims19
An antibody or antigen binding fragment thereof that specifically binds glypican-2 (GPC2), comprising a single variable domain on a heavy chain (VHH) domain comprising a complementary determining region (CDR)1, a CDR2, and a CDR3, wherein:
- the CDR1 comprises SEQ ID NO:
- 3, the CDR2 comprises SEQ ID NO:
- 33, and the CDR3 comprises SEQ ID NO:
- 64.
Dependencies are inferred from the claim text.