Anti-CD40 antibodies and methods of use

A humanized monoclonal antibody that binds to CD40 and is a CD40 agonist, comprising:

• (i) a heavy chain variable region comprising the VHCDR1 region set forth in SEQ ID NO:
• 3, the VHCDR2 region set forth in SEQ ID NO:4, and the VHCDR3 region set forth SEQ ID NO:
• 5;
• (ii) a light chain variable region comprising the VLCDR1 region set forth in SEQ ID NO:
• 6, the VLCDR2 region set forth in SEQ ID NO:7, and the VLCDR3 region set forth in SEQ ID NO:
• 8;
• and
• (iii) a human IgG1 heavy chain constant region comprising the amino acid sequence set forth in SEQ ID NO:
• 195.