Antibodies targeting integrin beta-2
OwnerSachdev Singh Sidhuinventor
Life of this patent
Estimating the term…
Abstract
Provided herein are antibodies that specifically target integrin beta-2 and compositions comprising such antibodies for therapeutic and diagnostic applications. The antibodies comprise an integrin beta-2 binding domain comprising a heavy chain variable region comprising an HCDR1 sequence comprising ISYYYM, an HCDR2 sequence comprising SISSSSGYTY; and an HCDR3 sequence comprising GAM; and a light chain variable region comprising an LCDR1 sequence comprising SVSSA, an LCDR2 sequence comprising SASSLYS; and an LCDR3 sequence comprising FSSGSWAPI.
Claims20
An antibody that specifically binds to integrin beta-2, wherein the antibody comprises an integrin beta-2 binding domain comprising:
- a heavy chain variable region (VH) comprising an HCDR1 sequence comprising amino acid sequence SEQ ID NO:
- 16, an HCDR2 sequence comprising amino acid sequence SEQ ID NO:
- 17;
- and an HCDR3 sequence comprising GAM;
- and
- a light chain variable region (VL) comprising an LCDR1 sequence comprising amino acid sequence SEQ ID NO:
- 18, an LCDR2 sequence comprising amino acid sequence SEQ ID NO:
- 19;
- and an LCDR3 sequence comprising amino acid sequence SEQ ID NO:
- 20.
A nucleic acid encoding an antibody VH and/or VL, wherein the VH comprises an HCDR1 sequence comprising amino acid sequence SEQ ID NO:
- 16, an HCDR2 sequence comprising amino acid sequence SEQ ID NO:
- 17;
- and an HCDR3 sequence comprising GAM;
- and
- wherein the VL comprises an LCDR1 sequence comprising amino acid sequence SEQ ID NO:
- 18, an LCDR2 sequence comprising amino acid sequence SEQ ID NO:
- 19;
- and an LCDR3 sequence comprising amino acid sequence SEQ ID NO:
- 20.
Dependencies are inferred from the claim text.