Antigen binding proteins which bind to the pMHC HLA-DQ2.5:DQ2.5 presenting a gliadin peptide
AssigneeUniversitetet I Oslo
InventorsGeir Åge Løset, Lene Støkken Høydahl, Inger Sandlie, Ludvig Magne Sollid, Rahel Frick
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Abstract
The present invention relates generally to the field of antigen binding proteins such as antibodies, in particular those which bind to HLA-DQ2.5:DQ2.5-glia-α1a, or which bind to HLA-DQ2.5:DQ2.5-glia-α2. The invention further relates to compositions and immunoconjugates comprising such antibodies and to methods of producing such antibodies. The invention also relates to methods and uses which employ such antibodies, for example in the treatment of celiac disease.
Claims10
An antibody, wherein said antibody binds to HLA-DQ2.5:DQ2.5 presenting an α2 gliadin peptide (HLA-DQ2.5:DQ2.5-glia-α2), and wherein said antibody comprises at least one heavy chain variable region that comprises three CDRs and at least one light chain variable region that comprises three CDRs;
- wherein said light chain variable region comprises:
- (a) a variable light (VL) CDR1 of SEQ ID NO:368,
- (b) a VL CDR2 of SEQ ID NO:369, and
- (c) a VL CDR3 of SEQ ID NO:370;
- and
- wherein said heavy chain variable region comprises:
- (d) a variable heavy (VH) CDR1 of SEQ ID NO:365,
- (e) a VH CDR2 of SEQ ID NO:366, and
- (f) a VH CDR3 of SEQ ID NO:367.
An antigen binding protein, wherein said antigen binding protein binds to HLA-DQ2.5:DQ2.5 presenting an α2 gliadin peptide (HLA-DQ2.5:DQ2.5-glia-α2), and wherein said antigen binding protein comprises at least one heavy chain variable region that comprises three CDRs and at least one light chain variable region that comprises three CDRs;
- wherein said light chain variable region comprises:
- (a) a variable light (VL) CDR1 of SEQ ID NO:368,
- (b) a VL CDR2 of SEQ ID NO:369, and
- (c) a VL CDR3 of SEQ ID NO:370;
- and
- wherein said heavy chain variable region comprises:
- (d) a variable heavy (VH) CDR1 of SEQ ID NO:365,
- (e) a VH CDR2 of SEQ ID NO:366, and
- (f) a VH CDR3 of SEQ ID NO:367;
- and
- wherein the antigen binding protein is an scFv or a Fab fragment.
Dependencies are inferred from the claim text.