US 12,606,625 B2Granted

Antibody binding specifically to B7—H3 and use thereof

AssigneesY-Biologics Inc., IntoCell, Inc.

InventorsHyun Ju Lee, Eun-Young Shim, Yunjung Ko, Jin-Chul Youn, Jae Eun Park, Soo A Choi, Seok Ho Yoo, Dong Jung Lee, Yeung-Chul Kim, Youngja Song, Jisu Lee, Ju-Ry Lim, Bum-Chan Park, Young Woo Park

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Abstract

Provided are an anti-B7-H3 antibody binding specifically to B7-H3 and a use thereof and, more particularly, are an anti-B7-H3 antibody or an antigen binding fragment thereof, a nucleic acid encoding the same, a vector carrying the nucleic acid, a cell transformed with the vector, a method for preparing the same, an antibody-drug conjugate or a multi-specific antibody comprising the same, and a pharmaceutical composition for preventing or treating cancer, autoimmune disease, or inflammatory disease, or a diagnostic composition, each composition comprising the same. The anti-B7-H3 antibody or antigen binding fragment thereof can bind to human and non-human B7-H3 at high affinity and can be endocytosized after binding thereto. Thus, the anti-B7-H3 antibody or antigen binding fragment thereof, or the antibody-drug conjugate or the multi-specific antibody comprising the same can be advantageously used for preventing, treating, or diagnosing cancer or tumor, autoimmune disease, or inflammatory disease.

An anti-B7-H3 antibody or an antigen binding fragment thereof comprising:

a heavy chain CDR (complementarity determining region) 1 of SEQ ID NO:
1, a heavy chain CDR2 of SEQ ID NO:
2, a heavy chain CDR3 of SEQ ID NO:
3, a light chain CDR1 of SEQ ID NO:
4, a light chain CDR2 of SEQ ID NO:
5, and a light chain CDR3 of SEQ ID NO:
6;
a heavy chain CDR1 of SEQ ID NO:
7, a heavy chain CDR2 of SEQ ID NO:
8, a heavy chain CDR3 of SEQ ID NO:
9, a light chain CDR1 of SEQ ID NO:
10, a light chain CDR2 of SEQ ID NO:
11, and a light chain CDR3 of SEQ ID NO:
12;
a heavy chain CDR1 of SEQ ID NO:
13, a heavy chain CDR2 of SEQ ID NO:
14, a heavy chain CDR3 of SEQ ID NO:
15, a light chain CDR1 of SEQ ID NO:
16, a light chain CDR2 of SEQ ID NO:
17, and a light chain CDR3 of SEQ ID NO:
18;
a heavy chain CDR1 of SEQ ID NO:
19, a heavy chain CDR2 of SEQ ID NO:
20, a heavy chain CDR3 of SEQ ID NO:
21, a light chain CDR1 of SEQ ID NO:
22, a light chain CDR2 of SEQ ID NO:
11, and a light chain CDR3 of SEQ ID NO:
23;
a heavy chain CDR1 of SEQ ID NO:
19, a heavy chain CDR2 of SEQ ID NO:
20, a heavy chain CDR3 of SEQ ID NO:
21, a light chain CDR1 of SEQ ID NO:
24, a light chain CDR2 of SEQ ID NO:
11, and a light chain CDR3 of SEQ ID NO:
25;
a heavy chain CDR1 of SEQ ID NO:
19, a heavy chain CDR2 of SEQ ID NO:
20, a heavy chain CDR3 of SEQ ID NO:
21, a light chain CDR1 of SEQ ID NO:
26, a light chain CDR2 of SEQ ID NO:
11, and a light chain CDR3 of SEQ ID NO:
27;
a heavy chain CDR1 of SEQ ID NO:
19, a heavy chain CDR2 of SEQ ID NO:
20, a heavy chain CDR3 of SEQ ID NO:
21, a light chain CDR1 of SEQ ID NO:
28, a light chain CDR2 of SEQ ID NO:
5, and a light chain CDR3 of SEQ ID NO:
29;
a heavy chain CDR1 of SEQ ID NO:
19, a heavy chain CDR2 of SEQ ID NO:
20, a heavy chain CDR3 of SEQ ID NO:
21, a light chain CDR1 of SEQ ID NO:
30, a light chain CDR2 of SEQ ID NO:
31, and a light chain CDR3 of SEQ ID NO:
32;
a heavy chain CDR1 of SEQ ID NO:
19, a heavy chain CDR2 of SEQ ID NO:
20, a heavy chain CDR3 of SEQ ID NO:
21, a light chain CDR1 of SEQ ID NO:
33, a light chain CDR2 of SEQ ID NO:
11, and a light chain CDR3 of SEQ ID NO:
34;
or
a heavy chain CDR1 of SEQ ID NO:
19, a heavy chain CDR2 of SEQ ID NO:
20, a heavy chain CDR3 of SEQ ID NO:
21, a light chain CDR1 of SEQ ID NO:
35, a light chain CDR2 of SEQ ID NO:
11, and a light chain CDR3 of SEQ ID NO:
36.

68 more elements

Abstract

Claims15