Human monoclonal antibodies against TIGIT for immune related diseases
AssigneeHuahui Health Ltd.
InventorsJianhua Sui, Fang Yang, Linlin Zhao, Zhizhong Wei
Life of this patent
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Abstract
The present invention relates to anti-TIGIT antibodies and antigen-binding fragments thereof that bind to both human TIGIT and mouse TIGIT. The present application also provides are nucleotides encoding the antibodies or fragments thereof, compositions or combinations comprising the antibodies or fragments thereof, and uses of the antibodies or fragments thereof in treatment of immune-related disease such as cancers and viral infection.
Claims21
An isolated antibody or an antigen-binding fragment thereof which binds to human TIGIT (T cell immunoreceptor with Ig and ITIM domain) and mouse TIGIT, comprising any of the following:
- (1) a VH comprising an HCDR1 having the amino acid sequence of SEQ ID NO:
- 18, an HCDR2 having the amino acid sequence of SEQ ID NO:
- 19, and an HCDR3 having the amino acid sequence of SEQ ID NO:
- 20;
- and a VL comprising an LCDR1 having the amino acid sequence of SEQ ID NO:
- 23, an LCDR2 having the amino acid sequence of SEQ ID NO:
- 24, and an LCDR3 having the amino acid sequence of SEQ ID NO:
- 25;
- (2) a VH comprising an HCDRI having the amino acid sequence of SEQ ID NO:
- 18, an HCDR2 having the amino acid sequence of SEQ ID NO:
- 19, and an HCDR3 having the amino acid sequence of SEQ ID NO:
- 20;
- and a VL comprising an LCDR1 having the amino acid sequence of SEQ ID NO:
- 30, an LCDR2 having the amino acid sequence of SEQ ID NO:
- 31, and an LCDR3 having the amino acid sequence of SEQ ID NO:
- 32;
- or
- (3) a VH comprising an HCDR1 having the amino acid sequence of SEQ ID NO:
- 18, an HCDR2 having the amino acid sequence of SEQ ID NO:
- 19, and an HCDR3 having the amino acid sequence of SEQ ID NO:
- 20;
- and a VL comprising an LCDR1 having the amino acid sequence of SEQ ID NO:
- 15, an LCDR2 having the amino acid sequence of SEQ ID NO:
- 16, and an LCDR3 having the amino acid sequence of SEQ ID NO:
- 17.
Dependencies are inferred from the claim text.