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US 12,606,609 B2Granted
Polypeptides having improved properties
AssigneeChiesi Farmaceutici S.p.A.
InventorsTore Curstedt, Jan Johansson
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Abstract
The present invention is directed to polypeptides having the properties of both SP-C and SP-B surfactant proteins and to the corresponding reconstituted surfactants. The invention is also directed to the pharmaceutical compositions thereof and to their use for the treatment or prophylaxis of neonatal respiratory distress syndrome (RDS) or other respiratory disorders such as acute RDS.
Claims30
A polypeptide represented by the general formula (I):
- (SEQ ID NO:
- 7)
- FqPqIqPqLqPqYqLWLΦZALIZZIQAΩIPZGGZΩLPQLVΦZLVLZLS
- (GS)nGrIPSSPVHLZZXBXXXXXXXXXXXXXXGALLΩpGpLp (I),
- wherein:
- Ω is an amino acid residue independently selected from the group consisting of M, M oxidized on the sulfur atom, I, L and Nle;
- Φ is an amino acid residue independently selected from the group consisting of L, I, and C;
- X is an amino acid residue independently selected from the group consisting of I, L, and Nle;
- B is an amino acid residue independently selected from the group consisting of K, R, H, W, F, Y, and Orn;
- Z is an amino acid independently selected from K or R;
- each p and q is independently 0 or 1;
- n is an integer between 1 and 8;
- and
- r is 0 or 1.
11 more elements
Dependencies are inferred from the claim text.