Recombinant CCN domain proteins and fusion proteins

A monomeric fusion protein comprising:

• (i) a polypeptide having 40 to 60 amino acids in length and comprising:
• (a) an amino acid sequence selected from SEQ ID NOs:
• 37 or 2 to 6;
• or (b) an amino acid sequence having at least 90% sequence identity to a sequence selected from SEQ ID NOs:
• 37 or 2 to 6;
• wherein all of the cysteine residues in said sequence selected from SEQ ID NOs:
• 37 or 2 to 6 are conserved;
• (ii) a monomeric fusion partner N- or C-terminally fused to the amino acid sequence of (i);
• and
• (iii) optionally a peptide linker between the polypeptide of (i) and the monomeric fusion partner of (ii),
• wherein the monomeric fusion partner of (ii) and the peptide linker of (iii) are not or do not comprise an IGF binding protein homology domain, a von Willebrand factor type C repeat homology domain, or a cysteine knot domain of a CCN family protein.