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US 12,606,599 B2Granted
Over-expression of GDS1 in yeast for increased ethanol and decreased acetate production
AssigneeDanisco US Inc.
InventorsZhongqiang Chen, Min Qi, Luan Tao, Quinn Qun Zhu
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Abstract
Described are compositions and methods relating to modified yeast that over-express the glycerol-deficient suppressor, GDS1. The yeast produces an increased amount of ethanol and a deceased amount of acetate compared to parental cells. Such yeast is particularly useful for large-scale ethanol production from starch substrates where acetate in an undesirable end product.
Claims12
A method for increasing the production of ethanol from yeast cells grown on a carbohydrate substrate, comprising:
- introducing into parental yeast cells a genetic alteration that increases the production of glycerol-deficient suppressor (GDS1) polypeptides compared to the amount produced in the parental cells;
- wherein the GDS1 polypeptides comprise an amino acid sequence having at least 80% sequence identity to the amino acid sequence set forth by SEQ ID NO:
- 1;
- and
- wherein the yeast cells are of a Saccharomyces spp.
2 more elements
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