Chimeric klebicins
AssigneeBactoclear Holdings PTE. Ltd
InventorsAnisha Ambady, Chemira Biddappa Appaiah, Vivek Daniel Paul, R. Sanjeev Saravanan, Keerthana Anbalagan
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Abstract
The present invention provides chimeric klebicins by combining translocation, receptor-binding, and bactericidal domains originated from different klebicins to achieve improved target cell range and bactericidal activity. Also provided are related compositions, kits, and methods of use of these chimeric klebicins.
Claims15
A polypeptide comprising one or more translocation domains, one or more receptor-binding domains, and a killing domain, wherein each of the domains is derived from a naturally-occurring klebicin, wherein the killing domain and at least one of the receptor-binding domains are derived from two different naturally-occurring klebicins, and wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:
- 45.
Dependencies are inferred from the claim text.