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US 12,606,597 B2Granted
Vaccines targeting Pseudomonas aeruginosa
AssigneeEvaxion Biotech A/S
InventorsNiels Iversen Møller, Andreas Holm Mattsson
Life of this patent
Estimating the term…
Abstract
Immunogenic proteins from Pseudomonas aeruginosa as well as nucleic acids, vectors and transformed cells useful for expression of the proteins. Also disclosed are methods for prophylaxis of infection with Pseudomonas aeruginosa using the proteins, nucleic acids, vectors or transformed cell.
Claims12
A pharmaceutical composition comprising an immunological adjuvant and a polypeptide, wherein the polypeptide comprises:
- a) an amino acid sequence, which consists of residues 24-682 of SEQ ID NO:
- 10, or
- b) an amino acid sequence consisting of at least or exactly 35 contiguous amino acid residues from residues 24-682 of SEQ ID NO:
- 10, or
- c) an amino acid sequence having a sequence identity of at least 80% with the amino acid sequence of a) or with the amino acid sequence of b),
- wherein, said polypeptide is antigenic in a mammal, and wherein, the amino acid sequence comprises at least one amino acid residue selected from
- I corresponding to the I in position 30 in SEQ ID NO:
- 10;
- V corresponding to the V in position 155 in SEQ ID NO:
- 10;
- V corresponding to the V in position 163 in SEQ ID NO:
- 10;
- S corresponding to the S in position 181 in SEQ ID NO:
- 10;
- A corresponding to the A in position 226 in SEQ ID NO:
- 10;
- P corresponding to the P in position 381 in SEQ ID NO:
- 10;
- P corresponding to the P in position 510 in SEQ ID NO:
- 10;
- S corresponding to the S in position 549 in SEQ ID NO:
- 10;
- L corresponding to the L in position 569 in SEQ ID NO:
- 10;
- and
- D corresponding to the D in position 570 in SEQ ID NO:
- 10.
24 more elements
Dependencies are inferred from the claim text.