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US 12,606,590 B2Granted
MRNA 5′-end cap analogs, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule or peptide
AssigneesUniwersytet Warszawski, Explorna Therapeutics Sp. z o.o.
InventorsMarcin Warminski, Pawel Sikorski, Joanna Kowalska, Jacek Jemielity
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Abstract
The invention relates to new mRNA 5′ end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method encompasses translation of the RNA molecule.
Claims14
A compound of formula:
- wherein:
- R1, R2, R3 and R4 are selected from the group consisting of:
- H, CH3 and alkyl, where R substituents with different numbers may be the same or different,
- n is 0 or 1,
- R5 is selected from the group consisting of:
- benzyl, substituted benzyl, 1-naphthylmethyl, 2-naphtylmethyl, substituted naphthylmethyl, alkylaryl, aryl,
- Base1 and Base2 are independently selected from the group consisting of:
- X1 and X3, are selected from the group consisting of:
- O, S, Se, whereby X substituents with different numbers may be the same or different,
- X2, X4 and X5 are selected from the group consisting of:
- O, S, Se, BH3, wherein X substituents with different numbers can be the same or different,
- X6 is selected from the group consisting of:
- O, CH2, CF2, CCl2.
10 more elements
Dependencies are inferred from the claim text.