Fluorinated hexoses

A compound of general formula (1-man) or (1-gal) or a salt thereof:

• wherein
• f is Hor F;
• X is in each instance independently chosen from hydrogen and a linear, branched, or cyclic C1- 4acyl or alkyl wherein each carbon atom is optionally substituted by a halogen, an alkoxy, or a haloalkoxy moiety, and wherein the acyl or alkyl is optionally unsaturated;
• Xn is —O—X, —NH2, —NH—C1-4alkyl, —N(C1-4alkyl)2, —NH—C1-4acyl, or —N(C1-4acyl)2 wherein each carbon atom is optionally substituted by a halogen, an alkoxy, or a haloalkoxy moiety, and wherein the acyl or alkyl is optionally unsaturated;
• L is O, S, NH, N(CH3), CH2, CHF, or CF2;
• Q is O or S;
• Z1 and Z2 are each independently chosen from
• hydrogen,
• benzyl or a linear, branched, or cyclic C1-6 acyl, alkyl, alkenyl, or alkynyl, wherein each carbon atom is optionally substituted by a halogen, an alkoxy, or a haloalkoxy moiety,
• a C1-4alkyl-Q′-C1-4acyl or a C1-4alkyl-Q′-C1-4alkyl, wherein each carbon atom is optionally substituted by a halogen, an alkoxy, or a haloalkoxy moiety, and wherein Q′ is O or —O—C(═O)—O— or S or —S—S—,
• or Z1 and Z2 together form a C1-4alkyl bridging moiety that is optionally substituted with halogen or a C1-10hydrocarbon,
• or Z1 is H and Z2 together with the O to which it is attached form a nucleotide;
• or OZ1 is an N-linked amino acid.