Method for synthesizing zirconium complex

A method for synthesizing a zirconium complex, the method comprising setting a temperature of a mixed solution at a certain temperature or more to synthesize a zirconium complex, the mixed solution being obtained by mixing:

• an organic solvent containing methanol having a concentration of 20% by volume or more and 95% by volume or less to the mixed solution or ethanol having a concentration of 40% by volume or more and 95% by volume or less to the mixed solution;
• a chelating agent solution in which a chelating agent containing a structure represented by General Formula (1) or General Formula (2) is dissolved;
• and
• zirconium dissolved in an acidic solution,
• in General Formula (1), R1, R2, R3, and R4 are each hydrogen, a —CH— group, a —(CH2)nCH— group, a —C(═O)(CH2)nCH— group, or a —(CH2)nC(═O)N— group;
• n is an integer of 0 or more;
• R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, and R20 are each selected from the structures represented by General Formulae (4) to (26), at least two of R5 to R12 are selected from the structures represented by General Formulae (4) to (21), R in each of General Formulae (16) to (21) and (26) is selected from the structures represented by Chemical Formulae (27) to (47);
• n of General Formulae (4) to (21), and (23) to (47) is an integer of 0 or more;
• a PET probe or a functional group facilitating bonding of a PET probe is optionally added to a functional group contained in R5 to R20;
• the functional group facilitating bonding is a carboxylic acid, a succinimide carboxylate, a tetrafluorophenol carboxylate, an alcohol, an amine, a thiol, an isothiocyanate, maleimide, phenol, aniline, benzoic acid, phenyl isothiocyanate, or an alkyne, an azide, dibenzocyclooctyne (DBCO), bicyclononyne (BCN), trans-cyclooctene (TCO), norbornene, tetrazine, or methyltetrazine, which are each a click chemistry reagent;
• and R5 to R20 optionally have a structure of the functional group facilitating bonding or a condensed structure of a PET probe and the functional group facilitating bonding, and
• in General Formula (2), R21, R22, and R23 are each hydrogen, a —CH— group, a —(CH2)nCH— group, a —C(═O)(CH2)nCH— group, or a —(CH2)nC(═O)N— group;
• n is an integer of 0 or more;
• R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, and R35 are each selected from the structures represented by General Formulae (4) to (26), R in each of General Formulae (16) to (21) and (26) being selected from the structures represented by Chemical Formulae (27) to (47);
• n of General Formulae (4) to (21), and (23) to (47) is an integer of 0 or more;
• a PET probe or a functional group facilitating bonding of a PET probe is optionally added to a functional group contained in R24 to R35;
• the functional group facilitating bonding is the following functional group:
• a carboxylic acid, a succinimide carboxylate, a tetrafluorophenol carboxylate, an alcohol, an amine, a thiol, an isothiocyanate, maleimide, phenol, aniline, benzoic acid, phenyl isothiocyanate, or an alkyne, an azide, DBCO, BCN, TCO, norbornene, tetrazine, or methyltetrazine, which are each a click chemistry reagent;
• and R24 to R35 optionally have a structure of the functional group facilitating bonding or a condensed structure of a PET probe and the functional group facilitating bonding,