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US 12,606,567 B2Granted
Salts and forms of a WEE1 inhibitor
AssigneeRecurium IP Holdings, LLC
InventorsChad Daniel Hopkins, Peter Qinhua Huang, Kevin Duane Bunker
Life of this patent
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Abstract
The salt, such as adipate salt Form A, and freebase forms of Compound A are WEE1 inhibitors. Such salts and/or forms and freebase forms, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
Claims23
(R)-2-allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo [3,4-d]pyrimidin-3-one (Compound A):
- wherein Compound A is selected from the group consisting of adipate salt Form A of Compound A, freebase Form E of Compound A, freebase Form F of Compound A and freebase Form J of Compound A, wherein:
- the adipate salt form A is characterized by one or more peaks in an X-ray powder diffraction pattern, wherein the one or more peaks are selected from 15.40 degrees 2θ ±0.2 degrees 2θ, 16.58 degrees 2θ ±0.2 degrees 2θ, 22.12 degrees 2θ ±0.2 degrees 2θ and 22.88 degrees 2θ ±0.2 degrees 2θ;
- and
- the freebase Form E of Compound A is a hydrate and is characterized by one or more peaks in an X-ray powder diffraction pattern, wherein the one or more peaks are selected from 6.20 degrees 2θ ±0.2 degrees 2θ, 12.40 degrees 2θ ±0.2 degrees 2θ, 18.96 degrees 2θ ±0.2 degrees 2θ and 22.62 degrees 2θ ±0.2 degrees 2θ;
- the freebase Form F of Compound A is characterized by one or more peaks in an X-ray powder diffraction pattern, wherein the one or more peaks are selected from 5.14 degrees 2θ ±0.2 degrees 2θ, 6.24 degrees 2θ ±0.2 degrees 2θ, 10.19 degrees 2θ ±0.2 degrees 2θ and 12.40 degrees 2θ ±0.2 degrees 2θ;
- and
- the freebase Form J is an anhydrate and is characterized by one or more peaks in an X-ray powder diffraction pattern, wherein the one or more peaks are selected from 6.08 degrees 2θ ±0.2 degrees 2θ, 10.58 degrees 2θ ±0.2 degrees 2θ, 19.42 degrees 2θ ±0.2 degrees 2θ, 21.93 degrees 2θ ±0.2 degrees 2θ and 23.23 degrees 2θ ±0.2 degrees 2θ.
4 more elements
Dependencies are inferred from the claim text.